I recently added a PopClip extension for dialing Skype to my collection. It scans selected text for a 7 or 10-digit phone number, offering a Skype button in the PopClip popup if it finds one. When activated, it dials the first match in the selected text.
It seems to be working quite well, so I’ve added it to the main collection, download below. The source is available on GitHub, but the script at the heart of it is simple, so I’ll post it here for reference:
The regex comes from a StackOverflow post. Once it finds a number, it just uses the Skype API to make the phone call. Easy, but handy.